Caspase 8

A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.

Also Known As:

Caspase-8; CAP4 Protease; FLICE Protein; MACH Protein; Mch5 Protease; Pro-Caspase-8; Procaspase-8; Pro Caspase 8; Procaspase 8

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Hydrolases: 2206
    - Peptide Hydrolases: 24289
      - Cysteine Proteases: 1994
        Cysteine Endopeptidases: 4
        Caspases: 9499
        Initiator Caspases: 34
        Caspase 8: 2483
      - Endopeptidases: 643
        Cysteine Endopeptidases: 4
        Caspases: 9499
        Initiator Caspases: 34
        Caspase 8: 2483
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Carrier Proteins: 13306
    - Signal Transducing Adaptor Proteins
      - Death Domain Receptor Signaling Adaptor Proteins: 4
        Caspase 8: 2483
  - Intracellular Signaling Peptides and Proteins: 32
    - Apoptosis Regulatory Proteins: 2581
      - Caspases: 9499
        Initiator Caspases: 34
        Caspase 8: 2483
      - Death Domain Receptor Signaling Adaptor Proteins: 4
        Caspase 8: 2483
    - Signal Transducing Adaptor Proteins
      - Death Domain Receptor Signaling Adaptor Proteins: 4
        Caspase 8: 2483

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Disease

Drug/Important Bio-Agent (IBA)